The .50 Browning Machine Gun cartridge is one hard-hitting bore. Loaded for automatic weapons and expansive rifles, this huge pig can truly connect with an objective and give it a hard smack. This overwhelming drawing back cartridge is not intended to be chambered for a handgun, but rather here we really have one. This gigantic single shot gun shoot the huge .50 BMG cartridge. We are extremely sure human wrists are not made for this sort of discipline. But to our surprise he survived with unharmed wrists to tell the story.